Saponins from the Gypsophila paniculata (baby’s breath) plant have been shown to significantly augment the cytotoxicity of immunotoxins and other targeted toxins directed against human cancer cells. The research groups of Professor Hendrik Fuchs ( Charité University, Berlin, Germany) and Dr David Flavell (Southampton General Hospital, United Kingdom) are working together toward the development of Gypsophila saponins for use in combination with immunotoxins or other targeted toxins for patients with leukaemia , lymphoma and other cancers .
Solubility enhancement of saikosaponin-a has also been observed in the presence of glycyrrhizic acid, which is the glucuronide monodesmoside saponin of licorice (Sasaki et al., 1988). The decrease in the degree of enhancement observed at high glycyrrhizic acid concentrations was attributed to the increase in solution viscosity (Sasaki et al., 1988). A solubilizing effect was also observed for the 30-β-glucoside (isolated from licorice roots) and glucuronide esters of glycyrrhizic acid at higher concentrations (Sasaki et al., 1988). In addition to bidesmosides, co-occuring compounds such as acyclic sesquiterpene oligoglycosides have also been shown to have a solubilizing effect on monodesmosides of Sapindus mukurossi (Kasai et al., 1986a) and Sapindus delavayl (Wong et al., 1991).