Health care costs are increasing, and approximately 30 percent of those costs are on wasted care. “Wasted care” is care that may not improve people’s health and in some cases may actually be harmful. First Choice Health has partnered with the Consumer Reports Choosing Wisely campaign. Choosing Wisely provides tools and resources to help you talk about your care options with your doctor(s) to ensure you receive care that’s right for you. Founded by the ABIM Foundation and supported by 60 different medical societies, Choosing Wisely offers topical articles and videos to help you make the most of your conversations with your doctor(s).
NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.