Los esteroides lipidos

Recent surveys and reports suggest that many athletes and bodybuilders abuse anabolic-androgenic steroids (AAS). However, scientific data on the cardiac and metabolic complications of AAS abuse are divergent and often conflicting. A total of 49 studies describing 1,467 athletes were reviewed to investigate the cardiovascular effects of the abuse of AAS. Although studies were typically small and retrospective, some associated AAS abuse with unfavorable effects. Otherwise healthy young athletes abusing AAS may show elevated levels of low-density lipoprotein and low levels of high-density lipoprotein. Although data are conflicting, AAS have also been linked with elevated systolic and diastolic blood pressure and with left ventricular hypertrophy that may persist after AAS cessation. Finally, in small case studies, AAS abuse has been linked with acute myocardial infarction and fatal ventricular arrhythmias. In conclusion, recognition of these adverse effects may improve the education of athletes and increase vigilance when evaluating young athletes with cardiovascular abnormalities.

Á esquerda funcionamento das hormonas esteroides (lípidos): (1) entrada na célula e (2) unión a unha proteína receptora no núcleo, causando (3) síntese de ARNm de certos xenes, que se traducirán a proteínas efectoras. Á dereita funcionamento das hormonas proteicas: (1) unión a receptores de membrana, que (2) inician unha vía de transdución. A vía de transdución acaba coa (3) activación de factores de transcrición no núcleo, e hai transcrición e tradución das proteínas efectoras. a = hormona, b = membrana plasmática, c = citoplasma, d = núcleo.

Los esteroides lipidos

los esteroides lipidos

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