Lung (pulmonary) inflammation affects the airways and lung tissue. Caused by the body’s immune response to injury or pathogens, inflammation can be acute (short-lasting) or chronic (long-lasting) in nature. Diseases associated with acute lung inflammation include acute lung infections, pneumonia, and acute respiratory distress syndrome (ARDS). Diseases associated with chronic lung inflammation include emphysema, chronic obstructive pulmonary disorder (COPD), pulmonary fibrosis, and lung cancer. Anyone can develop lung inflammation, but there are certain risk factors that increase one’s chances of developing this condition. These same risk factors can also make lung inflammation worse once a person has the condition.
NSAIDS with preferential cyclo-oxygenase 2 inhibitions have been developed. These include:
NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.