"It's very frightening. There seems to be no safe treatment window" for NSAIDs once you've had a heart attack, said Anne-Marie Schjerning Olsen, a cardiologist at Copenhagen University Hospital Gentofte who, along with colleagues, reviewed the records of nearly 100,000 patients who had suffered a heart attack between 1997 and 2009. About 44 percent of them received at least one prescription for an NSAID. Among people who didn't take NSAIDs, Olsen says, the cardiovascular risk after a first heart attack declines rapidly during the first year. "After five to 10 years it's almost the same" as the general population, she says. But heart attack survivors who took any NSAID other than low-dose aspirin had a higher risk of having a second heart attack or dying. The overall death risk rose 59 percent one year after the heart attack and 63 percent five years after, she said. Similarly, the risk of coronary death or a second heart attack rose 30 percent one year after the initial heart attack and 41 percent five years after.
Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines, and on the surface lining of the pelvic cavity. They also can be found in the vagina, cervix, and bladder. Endometriosis may not produce any symptoms, but when it does the most common symptom is pelvic pain that worsens just prior to menstruation and improves at the end of the menstrual period. Other symptoms of endometriosis include pain during sex, pain with pelvic examinations, cramping or pain during bowel movements or urination, and infertility.