-Paracetamol is metabolized primarily in the liver and partly in the kidneys, forming derivatives conjugated glucuronic and sulfonic. The excretion of paracetamol in urine under conjugated glucuronic form is about 50-80%, as conjugated sulfonic is about 20- 30%, unchanged <5%. A small fraction (<4%) is metabolized by cytochrome P450 under the action of N-acetyl metabolite parabenzoquinonimin, which is then detoxified by glutathione of liver quickly. However, with high doses of paracetamol, the metabolites are formed with enough concentration to deplete hepatic glutathione, and in that condition, its reaction with sulfhydryl hepatic protein increases and can lead to gangrene liver
Next came the flowers. I've never known an industry to have such conflicting information. Yes we can get tulips in September. No we can't get tulips in September. Yes we can get tulips but we can't say whether they will be fuchsia or pale pink. Hydrangeas will wilt for sure if they are not in a holder. Hydrangeas will wilt if they are not hand tied and kept in water. Hydrangeas will not wilt at all if they are high quality. Who am I suppose to believe? I'm still negotiating with the florist I chose. Who knew flowers would be the hardest part.